MIM1

Across CCLE and GDSC cell-line panels, response to MIM1 is significantly associated with the protein-level pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible MIM1 response-associated pathways across cancer lineages are Positive regulation of monoatomic ion transport, Positive regulation of calcium ion transport, and rRNA metabolic process, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MIM1 response versus Positive regulation of monoatomic ion transport protein-level pathway activity in OVARY (Pearson r = -0.65).

Protein-level pathway activity biomarkers of MIM1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of monoatomic ion transport →	-0.322	-0.710	<.001	<.001	3	10
OVARY	Positive regulation of calcium ion transport →	-0.371	-0.346	.020	.029	3	9
STOMACH	rRNA metabolic process →	+0.391	+0.649	.003	.003	3	8
STOMACH	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.298	+0.571	.005	.011	3	8
PANCREAS	Positive regulation of ubiquitin protein ligase activity →	+1.882	+0.871	.001	.044	3	8
PANCREAS	Positive regulation of glial cell differentiation →	+1.027	+0.799	.005	.007	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIM1 response vs Positive regulation of monoatomic ion transport — OVARY

Explore this scatter interactively →