Linsitinib

Across CCLE and GDSC cell-line panels, response to Linsitinib is significantly associated with the pathway activity of multiple pathways, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible Linsitinib response-associated pathways across cancer lineages are Wound healing, 'de novo' UMP biosynthetic process, and Maintenance of location, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Linsitinib response versus Wound healing pathway activity in SOFT_TISSUE (Pearson r = -0.54).

Pathway activity biomarkers of Linsitinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Wound healing →	-0.097	-0.822	.004	.011	3	10
BLOOD_Leukemia	'de novo' UMP biosynthetic process →	+0.058	+0.283	.001	.007	3	9
LIVER	Maintenance of location →	-0.078	-0.830	.049	.002	3	9
BONE	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.177	+0.804	.001	.003	3	9
KIDNEY	Positive regulation of protein exit from endoplasmic reticulum →	-0.173	-0.791	.012	.016	3	9
CNS	Maintenance of protein location →	-0.120	-0.764	.001	<.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Linsitinib response vs Wound healing — SOFT_TISSUE

Explore this scatter interactively →