Linifanib

Across CCLE and GDSC cell-line panels, response to Linifanib is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible Linifanib response-associated gene dependencies across cancer lineages are GABARAPL2, OR10J1, and RPGRIP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Linifanib response versus GABARAPL2 shRNA dependency in BLOOD_Leukemia (Pearson r = 0.56).

Shrna dependency biomarkers of Linifanib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GABARAPL2 →	+0.227	+2.088	.009	.031	3	7
LIVER	OR10J1 →	-0.233	-0.223	<.001	.047	3	6
BLOOD_Lymphoma	RPGRIP1 →	-0.193	-0.553	.001	.003	3	6
BLOOD_Leukemia	MGRN1 →	-0.232	-1.125	.002	.046	3	6
CNS	SFXN2 →	+0.226	+0.418	.021	.040	3	6
BLOOD_Leukemia	SGCB →	+0.213	+1.339	.003	.014	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Linifanib response vs GABARAPL2 — BLOOD_Leukemia

Explore this scatter interactively →