Linifanib

Across CCLE and GDSC cell-line panels, response to Linifanib is significantly associated with the protein abundance of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Linifanib response-associated proteins across cancer lineages are STX4, RRP1B, and EXOSC8, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Linifanib response versus STX4 protein abundance in BONE (Pearson r = -0.34).

Protein abundance biomarkers of Linifanib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	STX4 →	-0.897	-0.300	.020	.014	3	8
BREAST	RRP1B →	+0.656	+0.175	.003	.002	3	8
PANCREAS	EXOSC8 →	+0.692	+0.384	.001	<.001	3	8
OVARY	RPL31 →	+0.700	+0.206	.001	.012	3	8
STOMACH	SMC2 →	+1.424	+0.258	.010	.023	3	8
STOMACH	EMC7 →	-0.846	-0.285	.001	.031	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Linifanib response vs STX4 — BONE

Explore this scatter interactively →