Lapatinib

Across CCLE and GDSC cell-line panels, response to Lapatinib is significantly associated with the protein abundance of multiple proteins, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Lapatinib response-associated proteins across cancer lineages are HEXB, DDX18, and GNL3, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Lapatinib response versus HEXB protein abundance in URINARY_TRACT (Pearson r = -0.69).

Protein abundance biomarkers of Lapatinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HEXB →	-1.537	-1.008	<.001	.045	3	8
STOMACH	DDX18 →	+0.772	+0.994	.016	.015	3	8
OVARY	GNL3 →	+0.738	+1.105	.015	<.001	3	8
SKIN	ATP6V0D1 →	-0.732	-0.695	.001	.001	3	8
BREAST	UACA →	-1.211	-0.859	.002	.003	3	8
UPPER_AERODIGESTIVE_TRACT	KRT14 →	+3.989	+0.621	.004	.004	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Lapatinib response vs HEXB — URINARY_TRACT

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