LMP744

Across CCLE and GDSC cell-line panels, response to LMP744 is significantly associated with the protein-level pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible LMP744 response-associated pathways across cancer lineages are Fatty acid oxidation, Lipid oxidation, and Neuron projection extension, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, LMP744 response versus Fatty acid oxidation protein-level pathway activity in OVARY (Pearson r = -0.42).

Protein-level pathway activity biomarkers of LMP744 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Fatty acid oxidation →	-0.244	-1.051	.002	.010	3	9
OVARY	Lipid oxidation →	-0.245	-1.051	.002	.010	3	9
BONE	Neuron projection extension →	-0.358	-1.147	<.001	<.001	3	8
BREAST	rRNA metabolic process →	+0.266	+0.976	.002	.008	3	8
OVARY	Negative regulation of protein sumoylation →	-0.204	-0.757	.013	.018	3	8
OVARY	Negative regulation of proteasomal protein catabolic process →	+0.270	+1.247	.024	.003	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMP744 response vs Fatty acid oxidation — OVARY

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