LMB_AB2

Across CCLE and GDSC cell-line panels, response to LMB_AB2 is significantly associated with the total protein of multiple proteins, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible LMB_AB2 response-associated proteins across cancer lineages are YB-1_pS102, Caspase-7-cleavedD198, and TAZ, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, LMB_AB2 response versus YB-1_pS102 total protein in URINARY_TRACT (Pearson r = 0.79).

Total protein biomarkers of LMB_AB2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	YB-1_pS102 →	+0.672	+0.359	.006	.010	3	6
SOFT_TISSUE	Caspase-7-cleavedD198 →	+0.864	+0.446	.008	.001	3	6
SOFT_TISSUE	TAZ →	-0.857	-0.626	.001	<.001	3	5
LUNG_SCLC	Chk2_pT68 →	+0.395	+0.515	.043	.007	3	4
STOMACH	E-Cadherin →	-2.857	-0.453	.020	.027	3	4
OVARY	Transglutaminase →	-0.978	-0.560	.007	.015	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMB_AB2 response vs YB-1_pS102 — URINARY_TRACT

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