LIMK1 inhibitor BMS4

Across CCLE and GDSC cell-line panels, response to LIMK1 inhibitor BMS4 is significantly associated with the protein-level pathway activity of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible LIMK1 inhibitor BMS4 response-associated pathways across cancer lineages are Nucleic acid transport, RNA transport, and Establishment of RNA localization, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, LIMK1 inhibitor BMS4 response versus Nucleic acid transport protein-level pathway activity in LUNG_NSCLC_LUSC (Pearson r = 0.55).

Protein-level pathway activity biomarkers of LIMK1 inhibitor BMS4 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Nucleic acid transport →	+0.224	+0.382	.030	.020	3	8
LUNG_NSCLC_LUSC	RNA transport →	+0.224	+0.382	.030	.020	3	8
LUNG_NSCLC_LUSC	Establishment of RNA localization →	+0.224	+0.382	.030	.020	3	8
URINARY_TRACT	RNA export from nucleus →	+0.220	+0.324	.019	.040	3	8
LUNG_NSCLC_LUAD	mRNA transport →	+0.161	+0.211	.027	.046	3	8
BLOOD_Myeloma	Positive regulation of protein targeting to membrane →	-1.118	-0.346	.016	.027	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIMK1 inhibitor BMS4 response vs Nucleic acid transport — LUNG_NSCLC_LUSC

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