LGK974

Across CCLE and GDSC cell-line panels, response to LGK974 is significantly associated with the shRNA dependency of multiple gene dependencies, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible LGK974 response-associated gene dependencies across cancer lineages are MRPL37, JAG1, and HELLS, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, LGK974 response versus MRPL37 shRNA dependency in STOMACH (Pearson r = 0.41).

Shrna dependency biomarkers of LGK974 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRPL37 →	+0.328	+0.344	.033	.040	3	7
SOFT_TISSUE	JAG1 →	+0.260	+0.355	.002	.004	3	7
LARGE_INTESTINE	HELLS →	+0.218	+0.630	<.001	.007	3	7
LARGE_INTESTINE	DDX27 →	+0.740	+0.522	.005	.009	3	7
LUNG_NSCLC_LUSC	ADPGK →	-0.226	-0.669	<.001	.002	3	7
BLOOD_Lymphoma	ZNF493 →	+0.320	+0.237	.021	.013	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGK974 response vs MRPL37 — STOMACH

Explore this scatter interactively →