LGK974

Across CCLE and GDSC cell-line panels, response to LGK974 is significantly associated with the protein abundance of multiple proteins, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible LGK974 response-associated proteins across cancer lineages are GNAS, ITGA3, and RRAS, each associated with drug response in up to 14 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, LGK974 response versus GNAS protein abundance in STOMACH (Pearson r = -0.53).

Protein abundance biomarkers of LGK974 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GNAS →	-1.434	-0.599	<.001	.001	3	14
LUNG_NSCLC_LUAD	ITGA3 →	-2.575	-0.676	<.001	<.001	3	13
LIVER	RRAS →	-2.155	-0.782	.004	.002	3	13
BONE	RTN4 →	-1.299	-0.422	<.001	<.001	3	12
BONE	ALCAM →	-1.948	-0.383	<.001	<.001	3	11
BONE	PLEC →	-2.368	-0.446	<.001	<.001	3	11

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGK974 response vs GNAS — STOMACH

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