LGK974

Across CCLE and GDSC cell-line panels, response to LGK974 is significantly associated with the pathway activity of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible LGK974 response-associated pathways across cancer lineages are Regulation of intracellular transport, Amino acid metabolic process, and Positive regulation of intracellular transport, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, LGK974 response versus Regulation of intracellular transport pathway activity in LUNG_NSCLC_LUAD (Pearson r = -0.31).

Pathway activity biomarkers of LGK974 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of intracellular transport →	-0.050	-0.411	.001	.010	3	11
BONE	Amino acid metabolic process →	+0.055	+0.575	.022	.019	3	10
LUNG_NSCLC_LUAD	Positive regulation of intracellular transport →	-0.060	-0.472	.002	.018	3	10
STOMACH	Regulation of plasma membrane bounded cell projection assembly →	-0.041	-0.523	.011	.008	3	9
LIVER	Mitochondrial large ribosomal subunit assembly →	+0.121	+0.870	.013	.001	2	10
LIVER	Regulation of metallopeptidase activity →	-0.341	-1.000	.005	<.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGK974 response vs Regulation of intracellular transport — LUNG_NSCLC_LUAD

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