LDN-193189

Across CCLE and GDSC cell-line panels, response to LDN-193189 is significantly associated with the response to other drugs of multiple drugs, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible LDN-193189 response-associated drugs across cancer lineages are FTY-720, AT7867, and Flavopiridol, each associated with drug response in up to 17 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, LDN-193189 response versus FTY-720 response to other drugs in LIVER (Pearson r = 0.81).

Response to other drugs biomarkers of LDN-193189 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner drug	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FTY-720 →	+0.571	+0.582	.014	.013	3	17
SOFT_TISSUE	AT7867 →	+1.238	+0.436	.012	.034	3	15
KIDNEY	Flavopiridol →	+0.582	+0.407	.006	.022	3	15
OESOPHAGUS	Kobe2602 →	+0.501	+0.295	<.001	.019	3	15
UPPER_AERODIGESTIVE_TRACT	TWS119 →	+0.938	+0.210	.001	.004	3	14
OVARY	CAP-232 →	+0.688	+0.372	<.001	<.001	3	14

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LDN-193189 response vs FTY-720 — LIVER

Explore this scatter interactively →