KRAS (G12C) Inhibitor-12

Across CCLE and GDSC cell-line panels, response to KRAS (G12C) Inhibitor-12 is significantly associated with the total protein of multiple proteins, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible KRAS (G12C) Inhibitor-12 response-associated proteins across cancer lineages are Fibronectin, PAI-1, and ER-alpha_pS118, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KRAS (G12C) Inhibitor-12 response versus Fibronectin total protein in URINARY_TRACT (Pearson r = -0.64).

Total protein biomarkers of KRAS (G12C) Inhibitor-12 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Fibronectin →	-1.826	-0.798	.021	.002	3	7
BONE	PAI-1 →	-2.976	-1.145	.004	.002	3	6
STOMACH	ER-alpha_pS118 →	+0.350	+0.844	.002	.023	3	5
LARGE_INTESTINE	Smad1 →	+0.233	+0.516	.012	.042	3	5
LUNG_SCLC	c-Myc →	+0.805	+0.400	.032	.046	3	5
URINARY_TRACT	p27_pT157 →	+0.236	+0.867	.008	<.001	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRAS (G12C) Inhibitor-12 response vs Fibronectin — URINARY_TRACT

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