KIN001-270

Across CCLE and GDSC cell-line panels, response to KIN001-270 is significantly associated with the total protein of multiple proteins, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible KIN001-270 response-associated proteins across cancer lineages are E-Cadherin, C-Raf(MP05-739), and Snail, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-270 response versus E-Cadherin total protein in STOMACH (Pearson r = -0.54).

Total protein biomarkers of KIN001-270 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	E-Cadherin →	-2.532	-0.487	.016	.020	3	7
URINARY_TRACT	C-Raf(MP05-739) →	+0.397	+0.346	.035	.022	2	8
OVARY	Snail →	-0.313	-0.396	.005	.023	2	8
BONE	FASN →	+1.119	+0.829	.004	.042	2	7
OVARY	p70-S6K →	+0.562	+0.373	.019	.008	3	6
URINARY_TRACT	PI3K-p110-a →	+0.385	+0.470	.002	.025	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-270 response vs E-Cadherin — STOMACH

Explore this scatter interactively →