KIN001-266

Across CCLE and GDSC cell-line panels, response to KIN001-266 is significantly associated with the total protein of multiple proteins, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible KIN001-266 response-associated proteins across cancer lineages are p62 Lck ligand, 14-3-3_epsilon, and Annexin_VII, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-266 response versus p62 Lck ligand total protein in BLOOD_Lymphoma (Pearson r = -0.50).

Total protein biomarkers of KIN001-266 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	p62 Lck ligand →	-1.373	-0.417	.006	.004	3	7
BONE	14-3-3_epsilon →	+0.290	+1.352	.035	<.001	3	6
BLOOD_Leukemia	Annexin_VII →	-0.440	-0.293	.007	.012	3	6
BREAST	MSH2 →	+0.502	+0.489	.007	.018	3	5
LIVER	Akt →	+1.079	+0.862	.024	.024	3	5
BONE	HER2_pY1248 →	-0.581	-1.236	.001	.002	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-266 response vs p62 Lck ligand — BLOOD_Lymphoma

Explore this scatter interactively →