KIN001-266

Across CCLE and GDSC cell-line panels, response to KIN001-266 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible KIN001-266 response-associated pathways across cancer lineages are Regulation of epithelial cell differentiation involved in kidney development, Magnesium ion homeostasis, and Regulation of transcription by RNA polymerase III, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-266 response versus Regulation of epithelial cell differentiation involved in kidney development shRNA pathway dependency in LUNG_SCLC (Pearson r = -0.56).

Shrna pathway dependency biomarkers of KIN001-266 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of epithelial cell differentiation involved in kidney development →	-1.295	-0.542	.002	.011	3	7
LUNG_NSCLC_LUAD	Magnesium ion homeostasis →	-0.558	-0.460	.024	.001	3	7
BREAST	Regulation of transcription by RNA polymerase III →	-0.204	-0.521	.001	<.001	3	6
STOMACH	Eye morphogenesis →	-1.319	-0.631	.005	.048	2	7
BLOOD_Leukemia	Protein desumoylation →	-0.212	-0.219	.037	.016	3	6
LARGE_INTESTINE	Positive regulation of pinocytosis →	-1.061	-0.504	.003	.003	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-266 response vs Regulation of epithelial cell differentiation involved in kidney development — LUNG_SCLC

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