KIN001-266

Across CCLE and GDSC cell-line panels, response to KIN001-266 is significantly associated with the pathway activity of multiple pathways, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible KIN001-266 response-associated pathways across cancer lineages are Retrograde transport, endosome to Golgi, Establishment of protein localization to vacuole, and Post-Golgi vesicle-mediated transport, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-266 response versus Retrograde transport, endosome to Golgi pathway activity in KIDNEY (Pearson r = -0.63).

Pathway activity biomarkers of KIN001-266 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Retrograde transport, endosome to Golgi →	-0.067	-0.461	.014	.027	3	8
OESOPHAGUS	Establishment of protein localization to vacuole →	-0.077	-0.556	.017	.018	3	8
LUNG_NSCLC_LUAD	Post-Golgi vesicle-mediated transport →	-0.059	-0.551	<.001	.004	3	7
BONE	Endosomal transport →	-0.050	-0.980	.006	.029	2	8
LUNG_NSCLC_LUSC	Negative regulation of mononuclear cell migration →	-0.238	-0.929	.038	.022	3	7
BONE	Negative regulation of purine nucleotide biosynthetic process →	+0.207	+1.067	.028	.007	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-266 response vs Retrograde transport, endosome to Golgi — KIDNEY

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