KIN001-244

Across CCLE and GDSC cell-line panels, response to KIN001-244 is significantly associated with the total protein of multiple proteins, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible KIN001-244 response-associated proteins across cancer lineages are PI3K-p110-a, Snail, and XBP1, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-244 response versus PI3K-p110-a total protein in LUNG_NSCLC_LUSC (Pearson r = 0.71).

Total protein biomarkers of KIN001-244 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PI3K-p110-a →	+0.460	+0.619	.003	.013	3	5
BONE	Snail →	-0.726	-1.219	.001	<.001	3	5
LARGE_INTESTINE	XBP1 →	+0.356	+0.427	.008	.027	3	5
BONE	p62 Lck ligand →	-1.574	-1.007	.002	.022	3	5
BONE	Raptor →	+0.577	+1.004	.001	.038	3	5
BONE	b-Actin →	-1.565	-1.463	.018	.007	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-244 response vs PI3K-p110-a — LUNG_NSCLC_LUSC

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