KIN001-042

Across CCLE and GDSC cell-line panels, response to KIN001-042 is significantly associated with the RNA expression of multiple genes, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible KIN001-042 response-associated genes across cancer lineages are BCL2L1, GNG7, and DCUN1D3, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-042 response versus BCL2L1 RNA expression in URINARY_TRACT (Pearson r = -0.53).

Rna expression biomarkers of KIN001-042 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BCL2L1 →	-1.499	-0.197	.002	.031	3	9
SKIN	GNG7 →	-1.541	-0.327	.023	.006	3	9
KIDNEY	DCUN1D3 →	-0.610	-0.457	.040	.027	3	8
LUNG_NSCLC_LUAD	AHNAK2 →	-2.097	-0.380	<.001	<.001	3	8
LUNG_SCLC	LAT2 →	-1.825	-0.273	.007	.001	3	8
SKIN	H3C12 →	+0.492	+0.307	.001	.004	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-042 response vs BCL2L1 — URINARY_TRACT

Explore this scatter interactively →