KIN001-042

Across CCLE and GDSC cell-line panels, response to KIN001-042 is significantly associated with the shRNA pathway dependency of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible KIN001-042 response-associated pathways across cancer lineages are Positive regulation of type 2 immune response, Spleen development, and L-alanine catabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-042 response versus Positive regulation of type 2 immune response shRNA pathway dependency in LARGE_INTESTINE (Pearson r = -0.55).

Shrna pathway dependency biomarkers of KIN001-042 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of type 2 immune response →	-1.136	-0.364	.001	.007	3	7
SKIN	Spleen development →	+0.868	+0.230	.040	.038	3	7
BLOOD_Myeloma	L-alanine catabolic process →	+1.757	+0.394	<.001	.022	3	7
OVARY	Positive regulation of triglyceride catabolic process →	+1.045	+0.357	.006	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of MHC class II biosynthetic process →	-1.859	-0.266	<.001	.016	3	6
BONE	Vacuolar transport →	-0.231	-0.193	.040	.031	1	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-042 response vs Positive regulation of type 2 immune response — LARGE_INTESTINE

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