KIN001-042

Across CCLE and GDSC cell-line panels, response to KIN001-042 is significantly associated with the protein-level pathway activity of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible KIN001-042 response-associated pathways across cancer lineages are rRNA metabolic process, Ribosome biogenesis, and Nuclear-transcribed mRNA catabolic process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, KIN001-042 response versus rRNA metabolic process protein-level pathway activity in PANCREAS (Pearson r = 0.47).

Protein-level pathway activity biomarkers of KIN001-042 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	rRNA metabolic process →	+0.306	+0.439	.001	.011	3	9
PANCREAS	Ribosome biogenesis →	+0.242	+0.439	.007	.011	3	9
LUNG_NSCLC_LUSC	Nuclear-transcribed mRNA catabolic process →	+0.223	+0.232	.004	.028	3	8
LUNG_SCLC	tRNA decay →	+1.160	+0.341	.002	<.001	3	8
LUNG_SCLC	Ribosomal large subunit biogenesis →	+0.204	+0.273	.002	.004	3	8
PANCREAS	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+1.459	+0.471	.019	.017	2	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-042 response vs rRNA metabolic process — PANCREAS

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