JW-7-24-1

Across CCLE and GDSC cell-line panels, response to JW-7-24-1 is significantly associated with the total protein of multiple proteins, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible JW-7-24-1 response-associated proteins across cancer lineages are HER3, Rab25, and XBP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, JW-7-24-1 response versus HER3 total protein in STOMACH (Pearson r = -0.46).

Total protein biomarkers of JW-7-24-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HER3 →	-0.830	-0.811	.026	.027	2	7
UPPER_AERODIGESTIVE_TRACT	Rab25 →	-0.717	-0.614	<.001	.005	3	6
KIDNEY	XBP1 →	+0.337	+0.812	.003	.005	3	5
SOFT_TISSUE	Akt →	+0.697	+0.529	.004	.010	3	4
LARGE_INTESTINE	GSK-3b →	+0.427	+0.601	.028	.044	2	5
LUNG_NSCLC_LUSC	Cyclin-E2 →	+0.410	+0.674	<.001	.004	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JW-7-24-1 response vs HER3 — STOMACH

Explore this scatter interactively →