JQ1

Across CCLE and GDSC cell-line panels, response to JQ1 is significantly associated with the mutation status of multiple genes, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible JQ1 response-associated genes across cancer lineages are ACAN, MYO18B, and TP53, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, JQ1 response grouped by ACAN status in LUNG_SCLC.

Mutation status biomarkers of JQ1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACAN →	-3.115	-0.754	.011	.010	3	3
STOMACH	MYO18B →	-2.807	-0.840	.015	.003	3	3
BLOOD_Myeloma	TP53 →	-1.614	-1.031	.040	.038	3	2
KIDNEY	MUC16 →	-2.807	-0.631	.010	.004	3	2
SKIN	DNAH3 →	+2.169	+0.501	.018	.009	3	2
SKIN	FAT4 →	+3.169	+0.463	.004	.010	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JQ1 response by ACAN status — LUNG_SCLC

Explore this box plot interactively →