JNK Inhibitor VIII

Across CCLE and GDSC cell-line panels, response to JNK Inhibitor VIII is significantly associated with the RNA expression of multiple genes, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible JNK Inhibitor VIII response-associated genes across cancer lineages are BCL2L1, JRKL, and SLC35A2, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, JNK Inhibitor VIII response versus BCL2L1 RNA expression in SOFT_TISSUE (Pearson r = -0.74).

Rna expression biomarkers of JNK Inhibitor VIII response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BCL2L1 →	-1.812	-0.525	<.001	.002	3	11
OESOPHAGUS	JRKL →	-0.871	-0.425	.045	.046	3	9
LARGE_INTESTINE	SLC35A2 →	-0.584	-0.381	.008	.043	3	8
URINARY_TRACT	WFS1 →	-1.353	-0.339	.038	.044	3	8
SOFT_TISSUE	PXN →	-1.927	-0.476	.003	.002	3	8
STOMACH	KATNIP →	-0.794	-0.488	.014	.005	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JNK Inhibitor VIII response vs BCL2L1 — SOFT_TISSUE

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