JAK_8517

Across CCLE and GDSC cell-line panels, response to JAK_8517 is significantly associated with the RNA expression of multiple genes, with CNS cell lines showing a particularly strong set of associations.

The most reproducible JAK_8517 response-associated genes across cancer lineages are SAMD11, ARHGDIB, and ARHGAP29, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, JAK_8517 response versus SAMD11 RNA expression in CNS (Pearson r = 0.62).

Rna expression biomarkers of JAK_8517 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SAMD11 →	+2.842	+0.929	<.001	.004	3	8
BLOOD_Lymphoma	ARHGDIB →	-5.046	-0.947	<.001	.010	3	8
LUNG_NSCLC_LUSC	ARHGAP29 →	-3.097	-0.950	.011	.029	3	8
LARGE_INTESTINE	SLC49A4 →	-0.477	-0.692	.021	.006	3	8
BLOOD_Myeloma	ESYT2 →	-0.945	-0.745	.029	.011	3	7
OVARY	PTTG1IP →	-1.290	-1.192	.004	.002	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JAK_8517 response vs SAMD11 — CNS

Explore this scatter interactively →