JAK_8517

Across CCLE and GDSC cell-line panels, response to JAK_8517 is significantly associated with the protein-level pathway activity of multiple pathways, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible JAK_8517 response-associated pathways across cancer lineages are Leukocyte cell-cell adhesion, Nitric oxide metabolic process, and Positive regulation of fatty acid oxidation, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, JAK_8517 response versus Leukocyte cell-cell adhesion protein-level pathway activity in SOFT_TISSUE (Pearson r = -0.60).

Protein-level pathway activity biomarkers of JAK_8517 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Leukocyte cell-cell adhesion →	-0.375	-0.805	.004	.011	3	7
BONE	Nitric oxide metabolic process →	-0.278	-0.702	<.001	.009	3	7
CNS	Positive regulation of fatty acid oxidation →	-1.306	-1.030	.012	.004	3	7
CNS	Regulation of heart contraction →	-0.179	-0.812	.021	.002	3	7
URINARY_TRACT	Positive regulation of store-operated calcium channel activity →	-0.184	-1.138	.003	.005	3	7
URINARY_TRACT	Folic acid-containing compound biosynthetic process →	+0.445	+0.854	.019	.036	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JAK_8517 response vs Leukocyte cell-cell adhesion — SOFT_TISSUE

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