JAK3_7406

Across CCLE and GDSC cell-line panels, response to JAK3_7406 is significantly associated with the protein-level pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible JAK3_7406 response-associated pathways across cancer lineages are Folic acid-containing compound biosynthetic process, Translational initiation, and rRNA 5'-end processing, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, JAK3_7406 response versus Folic acid-containing compound biosynthetic process protein-level pathway activity in OVARY (Pearson r = 0.48).

Protein-level pathway activity biomarkers of JAK3_7406 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Folic acid-containing compound biosynthetic process →	+0.359	+0.548	.002	<.001	3	8
OVARY	Translational initiation →	+0.489	+0.615	.003	.001	3	7
PANCREAS	rRNA 5'-end processing →	+0.908	+0.624	.013	.001	3	7
LARGE_INTESTINE	Negative regulation of transcription by RNA polymerase I →	+0.156	+0.411	.030	.045	3	7
PANCREAS	mRNA cis splicing, via spliceosome →	+0.205	+0.715	.002	.006	3	7
PANCREAS	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.908	+0.624	.013	.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JAK3_7406 response vs Folic acid-containing compound biosynthetic process — OVARY

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