JAK1_8709

Across CCLE and GDSC cell-line panels, response to JAK1_8709 is significantly associated with the protein abundance of multiple proteins, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible JAK1_8709 response-associated proteins across cancer lineages are ARMC10, LMAN2L, and RPL38, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, JAK1_8709 response versus ARMC10 protein abundance in LIVER (Pearson r = -0.43).

Protein abundance biomarkers of JAK1_8709 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ARMC10 →	-1.123	-0.433	.003	.039	3	9
LUNG_SCLC	LMAN2L →	-1.042	-0.678	.002	<.001	3	8
LIVER	RPL38 →	+1.644	+0.689	.003	.002	3	8
BONE	NCEH1 →	-3.385	-0.480	.009	.009	3	8
LIVER	RPL23 →	+0.564	+0.520	.017	.009	3	8
SOFT_TISSUE	STIM1 →	-1.300	-0.988	.016	.021	2	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JAK1_8709 response vs ARMC10 — LIVER

Explore this scatter interactively →