Idelalisib

Across CCLE and GDSC cell-line panels, response to Idelalisib is significantly associated with the shRNA dependency of multiple gene dependencies, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Idelalisib response-associated gene dependencies across cancer lineages are ART3, CKAP5, and LRRFIP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Idelalisib response versus ART3 shRNA dependency in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.96).

Shrna dependency biomarkers of Idelalisib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ART3 →	-0.135	-0.521	.002	.012	3	7
CNS	CKAP5 →	-0.634	-0.379	.014	.021	3	7
CNS	LRRFIP1 →	+0.236	+0.354	.015	.006	3	6
LUNG_SCLC	ATP6AP2 →	-0.227	-0.615	.001	.009	3	6
BLOOD_Myeloma	AQP12B →	-0.500	-0.396	.016	.016	3	6
LUNG_SCLC	MAGEA6 →	+0.211	+0.598	.011	.010	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Idelalisib response vs ART3 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →