Idelalisib

Across CCLE and GDSC cell-line panels, response to Idelalisib is significantly associated with the protein-level pathway activity of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible Idelalisib response-associated pathways across cancer lineages are Cellular respiration, Response to methionine, and Response to X-ray, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Idelalisib response versus Cellular respiration protein-level pathway activity in LUNG_NSCLC_LUSC (Pearson r = -0.53).

Protein-level pathway activity biomarkers of Idelalisib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cellular respiration →	-0.240	-0.735	.031	.026	3	8
KIDNEY	Response to methionine →	+0.929	+0.561	.005	.011	3	7
CNS	Response to X-ray →	+0.159	+0.449	.002	<.001	3	7
KIDNEY	Cellular response to methionine →	+0.929	+0.561	.005	.011	3	7
BONE	Response to mechanical stimulus →	-0.157	-0.501	.022	.001	3	7
LUNG_NSCLC_LUAD	Fatty acid transmembrane transport →	-0.284	-0.379	.022	.015	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Idelalisib response vs Cellular respiration — LUNG_NSCLC_LUSC

Explore this scatter interactively →