IRAK4_4710

Across CCLE and GDSC cell-line panels, response to IRAK4_4710 is significantly associated with the pathway activity of multiple pathways, with CNS cell lines showing a particularly strong set of associations.

The most reproducible IRAK4_4710 response-associated pathways across cancer lineages are Intestinal epithelial cell development, Negative regulation of cytokine production, and Golgi localization, each associated with drug response in up to 12 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, IRAK4_4710 response versus Intestinal epithelial cell development pathway activity in CNS (Pearson r = -0.59).

Pathway activity biomarkers of IRAK4_4710 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Intestinal epithelial cell development →	-0.099	-0.348	.003	.014	3	12
CNS	Negative regulation of cytokine production →	-0.082	-0.547	.003	.026	3	8
BONE	Golgi localization →	-0.130	-0.413	.003	.008	3	8
CNS	Epithelial cell development →	-0.119	-0.625	.014	.013	3	8
BONE	Negative regulation of anoikis →	-0.123	-0.355	.004	.004	3	8
SOFT_TISSUE	Regulation of membrane tubulation →	-0.137	-0.414	.015	.027	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRAK4_4710 response vs Intestinal epithelial cell development — CNS

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