IOX2

Across CCLE and GDSC cell-line panels, response to IOX2 is significantly associated with the RNA expression of multiple genes, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible IOX2 response-associated genes across cancer lineages are HAS3, SHROOM3, and ATP23, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, IOX2 response versus HAS3 RNA expression in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.88).

Rna expression biomarkers of IOX2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HAS3 →	-2.829	-0.336	.038	.002	3	5
LUNG_NSCLC_LUAD	SHROOM3 →	-1.839	-0.744	.018	.002	3	5
LUNG_NSCLC_LUAD	ATP23 →	+0.745	+0.644	.029	.014	3	5
LUNG_NSCLC_LUAD	RPS26 →	+1.029	+0.862	.005	.002	3	5
BLOOD_Leukemia	CA2 →	-4.773	-0.311	.002	.018	3	5
BLOOD_Lymphoma	GDAP1 →	-1.362	-0.352	<.001	.022	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IOX2 response vs HAS3 — UPPER_AERODIGESTIVE_TRACT

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