IGFR_3801

Across CCLE and GDSC cell-line panels, response to IGFR_3801 is significantly associated with the protein-level pathway activity of multiple pathways, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible IGFR_3801 response-associated pathways across cancer lineages are Positive regulation of translation, Succinyl-CoA metabolic process, and Regulation of lipid catabolic process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, IGFR_3801 response versus Positive regulation of translation protein-level pathway activity in BLOOD_Lymphoma (Pearson r = 0.28).

Protein-level pathway activity biomarkers of IGFR_3801 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of translation →	+0.109	+0.797	.004	.018	3	9
BREAST	Succinyl-CoA metabolic process →	-0.313	-1.084	<.001	.001	3	8
PANCREAS	Regulation of lipid catabolic process →	-0.898	-0.393	.007	.030	3	8
BREAST	Regulation of androgen receptor signaling pathway →	+0.124	+0.634	.002	.013	3	8
BLOOD_Lymphoma	Membrane fusion →	-0.127	-0.974	.013	<.001	3	7
BONE	Regulation of transcription by RNA polymerase I →	+0.175	+0.472	.018	.021	2	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFR_3801 response vs Positive regulation of translation — BLOOD_Lymphoma

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