IGFR_3801

Across CCLE and GDSC cell-line panels, response to IGFR_3801 is significantly associated with the response to other drugs of multiple drugs, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible IGFR_3801 response-associated drugs across cancer lineages are IGF1R_3801, Foretinib, and BMS-754807, each associated with drug response in up to 19 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, IGFR_3801 response versus IGF1R_3801 response to other drugs in BLOOD_Myeloma (Pearson r = 0.74).

Response to other drugs biomarkers of IGFR_3801 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner drug	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IGF1R_3801 →	+1.903	+1.496	.007	.011	3	19
LUNG_NSCLC_LUSC	Foretinib →	+1.144	+0.485	.038	.040	3	19
BLOOD_Myeloma	BMS-754807 →	+1.791	+0.825	<.001	.027	3	19
STOMACH	FGFR_3831 →	+1.248	+1.100	<.001	<.001	3	18
STOMACH	PLK_6522 →	+1.238	+1.165	.007	.001	3	18
LUNG_SCLC	Alisertib →	+1.826	+1.240	<.001	<.001	3	17

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFR_3801 response vs IGF1R_3801 — BLOOD_Myeloma

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