ICL1100013

Across CCLE and GDSC cell-line panels, response to ICL1100013 is significantly associated with the shRNA dependency of multiple gene dependencies, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible ICL1100013 response-associated gene dependencies across cancer lineages are USP17L4, MMRN2, and AFF1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ICL1100013 response versus USP17L4 shRNA dependency in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.57).

Shrna dependency biomarkers of ICL1100013 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	USP17L4 →	-0.177	-1.037	.007	.008	3	8
KIDNEY	MMRN2 →	+0.136	+0.883	.015	.014	3	7
OVARY	AFF1 →	-0.158	-0.920	.022	.020	3	7
OVARY	PPEF1 →	+0.270	+0.946	.021	.011	3	7
LUNG_NSCLC_LUSC	TAS2R46 →	-0.200	-1.282	.046	.003	3	7
OESOPHAGUS	DDX21 →	+0.555	+0.609	.003	.008	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ICL1100013 response vs USP17L4 — UPPER_AERODIGESTIVE_TRACT

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