ICL1100013

Across CCLE and GDSC cell-line panels, response to ICL1100013 is significantly associated with the protein-level pathway activity of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible ICL1100013 response-associated pathways across cancer lineages are Nuclear polyadenylation-dependent rRNA catabolic process, TRAMP-dependent tRNA surveillance pathway, and rRNA metabolic process, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ICL1100013 response versus Nuclear polyadenylation-dependent rRNA catabolic process protein-level pathway activity in STOMACH (Pearson r = 0.44).

Protein-level pathway activity biomarkers of ICL1100013 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Nuclear polyadenylation-dependent rRNA catabolic process →	+1.792	+0.861	.003	.030	3	10
STOMACH	TRAMP-dependent tRNA surveillance pathway →	+1.792	+0.861	.003	.030	3	10
LUNG_NSCLC_LUSC	rRNA metabolic process →	+0.429	+1.185	.010	.004	3	10
BREAST	mRNA catabolic process →	+0.220	+0.759	<.001	<.001	3	10
BREAST	CUT catabolic process →	+1.061	+0.969	.001	<.001	3	9
OVARY	Organelle localization by membrane tethering →	-0.269	-0.709	<.001	.002	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ICL1100013 response vs Nuclear polyadenylation-dependent rRNA catabolic process — STOMACH

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