ICL-SIRT078

Across CCLE and GDSC cell-line panels, response to ICL-SIRT078 is significantly associated with the pathway activity of multiple pathways, with CNS cell lines showing a particularly strong set of associations.

The most reproducible ICL-SIRT078 response-associated pathways across cancer lineages are Rho protein signal transduction, Amino acid catabolic process, and Regulation of early endosome to late endosome transport, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ICL-SIRT078 response versus Rho protein signal transduction pathway activity in CNS (Pearson r = -0.48).

Pathway activity biomarkers of ICL-SIRT078 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Rho protein signal transduction →	-0.080	-0.784	.029	.008	3	8
PANCREAS	Amino acid catabolic process →	+0.074	+0.621	.007	.006	3	8
KIDNEY	Regulation of early endosome to late endosome transport →	-0.145	-1.177	.003	.005	3	7
UPPER_AERODIGESTIVE_TRACT	Vacuolar acidification →	-0.134	-0.799	.027	.037	3	7
UPPER_AERODIGESTIVE_TRACT	Carnitine transport →	-1.171	-0.587	.003	.017	3	7
UPPER_AERODIGESTIVE_TRACT	Carnitine transmembrane transport →	-1.171	-0.587	.003	.017	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ICL-SIRT078 response vs Rho protein signal transduction — CNS

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