IC-87114

Across CCLE and GDSC cell-line panels, response to IC-87114 is significantly associated with the shRNA pathway dependency of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible IC-87114 response-associated pathways across cancer lineages are Cerebellar cortex formation, Organic cation transport, and Response to L-glutamine, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, IC-87114 response versus Cerebellar cortex formation shRNA pathway dependency in BREAST (Pearson r = -0.42).

Shrna pathway dependency biomarkers of IC-87114 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cerebellar cortex formation →	-0.759	-0.318	.005	.001	3	6
BLOOD_Myeloma	Organic cation transport →	+1.709	+0.255	<.001	.044	3	6
BLOOD_Myeloma	Response to L-glutamine →	+1.823	+0.129	.018	.011	3	6
BLOOD_Myeloma	Cellular response to L-glutamine →	+1.823	+0.129	.018	.011	3	6
KIDNEY	Positive regulation of proteoglycan biosynthetic process →	-1.401	-0.350	<.001	.044	3	6
BLOOD_Leukemia	Regulation of AIM2 inflammasome complex assembly →	+0.613	+0.341	.024	.035	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IC-87114 response vs Cerebellar cortex formation — BREAST

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