I-CBP112

Across CCLE and GDSC cell-line panels, response to I-CBP112 is significantly associated with the RNA expression of multiple genes, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible I-CBP112 response-associated genes across cancer lineages are SH3TC2, PALD1, and RPL31, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, I-CBP112 response versus SH3TC2 RNA expression in STOMACH (Pearson r = -0.69).

Rna expression biomarkers of I-CBP112 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SH3TC2 →	-2.181	-0.487	<.001	.009	3	8
BONE	PALD1 →	+2.282	+0.385	.010	.018	3	8
BONE	RPL31 →	+0.842	+0.500	.017	.001	3	8
OESOPHAGUS	SH3GLB1 →	-0.863	-0.260	<.001	.003	3	7
LUNG_SCLC	RPL13A →	+0.578	+0.309	.004	.001	3	7
STOMACH	NCEH1 →	-2.551	-0.470	.006	.028	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

I-CBP112 response vs SH3TC2 — STOMACH

Explore this scatter interactively →