I-BRD9

Across CCLE and GDSC cell-line panels, response to I-BRD9 is significantly associated with the protein abundance of multiple proteins, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible I-BRD9 response-associated proteins across cancer lineages are EIF3E, BCL2L1, and LARS1, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, I-BRD9 response versus EIF3E protein abundance in LARGE_INTESTINE (Pearson r = 0.40).

Protein abundance biomarkers of I-BRD9 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3E →	+0.842	+0.436	.003	.020	3	11
PANCREAS	BCL2L1 →	-0.941	-0.544	.004	.022	3	10
LARGE_INTESTINE	LARS1 →	+0.710	+0.367	<.001	.008	3	10
PANCREAS	EXOSC4 →	+0.869	+0.732	.012	.004	3	9
CNS	DAXX →	+1.093	+0.462	<.001	.002	3	9
LARGE_INTESTINE	GRWD1 →	+0.581	+0.427	.033	.043	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

I-BRD9 response vs EIF3E — LARGE_INTESTINE

Explore this scatter interactively →