I-BRD9

Across CCLE and GDSC cell-line panels, response to I-BRD9 is significantly associated with the protein-level pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible I-BRD9 response-associated pathways across cancer lineages are Negative regulation of proteasomal protein catabolic process, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, and mRNA transcription by RNA polymerase II, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, I-BRD9 response versus Negative regulation of proteasomal protein catabolic process protein-level pathway activity in OVARY (Pearson r = 0.36).

Protein-level pathway activity biomarkers of I-BRD9 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of proteasomal protein catabolic process →	+0.260	+0.372	.009	.014	3	10
LUNG_SCLC	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.199	+0.598	<.001	<.001	3	10
STOMACH	mRNA transcription by RNA polymerase II →	-0.474	-0.481	.048	.004	3	9
STOMACH	tRNA metabolic process →	+0.181	+0.605	.006	.004	3	9
STOMACH	Protein localization to cell periphery →	-0.242	-0.434	.021	.035	3	9
STOMACH	Protein localization to plasma membrane →	-0.241	-0.604	.016	.005	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

I-BRD9 response vs Negative regulation of proteasomal protein catabolic process — OVARY

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