I-BET-762

Across CCLE and GDSC cell-line panels, response to I-BET-762 is significantly associated with the total protein of multiple proteins, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible I-BET-762 response-associated proteins across cancer lineages are Annexin_VII, XBP1, and CDK1, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, I-BET-762 response versus Annexin_VII total protein in BLOOD_Lymphoma (Pearson r = -0.41).

Total protein biomarkers of I-BET-762 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Annexin_VII →	-0.551	-0.755	.047	.022	3	5
LUNG_SCLC	XBP1 →	+0.300	+0.645	.014	.031	3	5
UPPER_AERODIGESTIVE_TRACT	CDK1 →	+0.396	+0.892	.024	.019	3	5
BLOOD_Lymphoma	VEGFR2 →	-1.177	-0.647	.017	.021	3	4
BONE	Akt_pT308 →	-0.612	-0.497	.011	.006	3	4
BREAST	Akt_pS473 →	-1.278	-0.413	.032	.045	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

I-BET-762 response vs Annexin_VII — BLOOD_Lymphoma

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