I-BET-151

Across CCLE and GDSC cell-line panels, response to I-BET-151 is significantly associated with the shRNA pathway dependency of multiple pathways, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible I-BET-151 response-associated pathways across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Regulation of natural killer cell mediated cytotoxicity, and CGMP metabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, I-BET-151 response versus Negative regulation of calcium ion export across plasma membrane shRNA pathway dependency in SKIN (Pearson r = -0.39).

Shrna pathway dependency biomarkers of I-BET-151 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of calcium ion export across plasma membrane →	-0.687	-0.488	.023	.022	3	7
SOFT_TISSUE	Regulation of natural killer cell mediated cytotoxicity →	+1.692	+0.589	<.001	.015	3	6
SOFT_TISSUE	CGMP metabolic process →	+1.533	+0.773	.008	.004	3	6
LARGE_INTESTINE	Netrin-activated signaling pathway →	+1.043	+0.754	.008	.009	3	6
BREAST	Positive regulation of nuclear cell cycle DNA replication →	-0.214	-0.452	.005	.007	3	6
BLOOD_Leukemia	Regulation of sister chromatid cohesion →	-0.391	-0.932	.002	.002	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

I-BET-151 response vs Negative regulation of calcium ion export across plasma membrane — SKIN

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