HG-5-88-01

Across CCLE and GDSC cell-line panels, response to HG-5-88-01 is significantly associated with the total protein of multiple proteins, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible HG-5-88-01 response-associated proteins across cancer lineages are Caspase-7-cleavedD198, b-Actin, and EGFR_pY1068, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, HG-5-88-01 response versus Caspase-7-cleavedD198 total protein in LARGE_INTESTINE (Pearson r = 0.31).

Total protein biomarkers of HG-5-88-01 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Caspase-7-cleavedD198 →	+0.491	+0.439	.025	.021	3	6
BLOOD_Leukemia	b-Actin →	+1.926	+1.050	.042	.008	3	5
STOMACH	EGFR_pY1068 →	-2.097	-0.669	.005	.020	3	5
SKIN	SETD2 →	+0.231	+0.723	.011	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	YAP_pS127 →	+1.717	+0.745	.008	.033	3	5
KIDNEY	Bax →	+0.705	+0.734	.027	.008	2	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HG-5-88-01 response vs Caspase-7-cleavedD198 — LARGE_INTESTINE

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