HG-5-88-01

Across CCLE and GDSC cell-line panels, response to HG-5-88-01 is significantly associated with the protein abundance of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible HG-5-88-01 response-associated proteins across cancer lineages are SYNE1, PPP1R18, and FARP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, HG-5-88-01 response versus SYNE1 protein abundance in LUNG_SCLC (Pearson r = -0.49).

Protein abundance biomarkers of HG-5-88-01 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SYNE1 →	-1.533	-0.383	.045	.020	3	7
BONE	PPP1R18 →	-1.205	-0.758	.002	<.001	3	7
BREAST	FARP1 →	-1.146	-0.572	.024	.003	3	6
LUNG_NSCLC_LUAD	SREK1 →	+0.705	+0.485	<.001	.001	3	6
SKIN	ALG5 →	+0.542	+0.432	.025	.005	3	6
LUNG_SCLC	ALDH16A1 →	+0.791	+0.410	.017	.015	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HG-5-88-01 response vs SYNE1 — LUNG_SCLC

Explore this scatter interactively →