HG-5-113-01

Across CCLE and GDSC cell-line panels, response to HG-5-113-01 is significantly associated with the total protein of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible HG-5-113-01 response-associated proteins across cancer lineages are E-Cadherin, VAV1, and MIG-6, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, HG-5-113-01 response versus E-Cadherin total protein in LUNG_SCLC (Pearson r = -0.38).

Total protein biomarkers of HG-5-113-01 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	E-Cadherin →	-1.302	-0.449	.027	.015	3	6
BONE	VAV1 →	+5.458	+0.654	<.001	.027	3	6
CNS	MIG-6 →	+0.520	+0.371	.023	.001	3	6
BONE	p38 alpha MAPK →	-0.231	-0.780	.043	.006	3	5
BONE	Caveolin-1 →	+2.730	+0.809	.030	.001	3	5
SKIN	PCNA →	+0.307	+0.508	.032	.006	2	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HG-5-113-01 response vs E-Cadherin — LUNG_SCLC

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