HG-5-113-01

Across CCLE and GDSC cell-line panels, response to HG-5-113-01 is significantly associated with the pathway activity of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible HG-5-113-01 response-associated pathways across cancer lineages are Nuclear polyadenylation-dependent rRNA catabolic process, TRAMP-dependent tRNA surveillance pathway, and Positive regulation of DNA metabolic process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, HG-5-113-01 response versus Nuclear polyadenylation-dependent rRNA catabolic process pathway activity in LUNG_SCLC (Pearson r = 0.73).

Pathway activity biomarkers of HG-5-113-01 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Nuclear polyadenylation-dependent rRNA catabolic process →	+0.188	+0.849	<.001	.011	3	9
LUNG_SCLC	TRAMP-dependent tRNA surveillance pathway →	+0.188	+0.849	<.001	.011	3	9
BONE	Positive regulation of DNA metabolic process →	+0.068	+0.706	.002	.005	3	8
BLOOD_Lymphoma	Regulation of hepatocyte proliferation →	-0.257	-1.004	.034	.004	3	8
LUNG_SCLC	rRNA modification →	+0.157	+0.909	.035	.003	3	8
LUNG_SCLC	U1 snRNA 3'-end processing →	+0.205	+0.623	.003	.013	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HG-5-113-01 response vs Nuclear polyadenylation-dependent rRNA catabolic process — LUNG_SCLC

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