Gallibiscoquinazole

Across CCLE and GDSC cell-line panels, response to Gallibiscoquinazole is significantly associated with the shRNA dependency of multiple gene dependencies, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible Gallibiscoquinazole response-associated gene dependencies across cancer lineages are SEC13, CD79A, and PHB2, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Gallibiscoquinazole response versus SEC13 shRNA dependency in OESOPHAGUS (Pearson r = 0.67).

Shrna dependency biomarkers of Gallibiscoquinazole response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SEC13 →	+0.424	+0.576	.012	<.001	3	7
LARGE_INTESTINE	CD79A →	-0.154	-0.519	.018	.003	3	6
LARGE_INTESTINE	PHB2 →	+0.301	+0.341	.003	.021	3	6
BONE	RPEL1 →	+0.246	+0.469	.018	.004	3	6
BLOOD_Leukemia	UBE3C →	-0.193	-0.542	.032	.001	3	6
LUNG_NSCLC_LUSC	ROCK2 →	+0.240	+0.723	.022	.021	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Gallibiscoquinazole response vs SEC13 — OESOPHAGUS

Explore this scatter interactively →