Gallibiscoquinazole

Across CCLE and GDSC cell-line panels, response to Gallibiscoquinazole is significantly associated with the shRNA pathway dependency of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Gallibiscoquinazole response-associated pathways across cancer lineages are C21-steroid hormone metabolic process, Proteasome assembly, and Negative regulation of epithelial cell differentiation, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Gallibiscoquinazole response versus C21-steroid hormone metabolic process shRNA pathway dependency in OVARY (Pearson r = 0.50).

Shrna pathway dependency biomarkers of Gallibiscoquinazole response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C21-steroid hormone metabolic process →	+1.089	+0.516	.031	.047	3	8
PANCREAS	Proteasome assembly →	-0.164	-0.462	.011	.006	3	7
OESOPHAGUS	Negative regulation of epithelial cell differentiation →	+0.797	+0.397	.022	.006	3	7
STOMACH	Regulation of angiotensin-activated signaling pathway →	+1.469	+0.504	.005	.003	3	7
BLOOD_Leukemia	Mesenchymal cell differentiation involved in kidney development →	-0.391	-0.595	.045	.004	3	7
BREAST	Developmental maturation →	-0.222	-0.471	.006	.007	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Gallibiscoquinazole response vs C21-steroid hormone metabolic process — OVARY

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