GW843682X

Across CCLE and GDSC cell-line panels, response to GW843682X is significantly associated with the pathway activity of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible GW843682X response-associated pathways across cancer lineages are Pancreatic juice secretion, DUMP metabolic process, and Process utilizing autophagic mechanism, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GW843682X response versus Pancreatic juice secretion pathway activity in LARGE_INTESTINE (Pearson r = -0.80).

Pathway activity biomarkers of GW843682X response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Pancreatic juice secretion →	-0.341	-1.633	.003	<.001	3	6
LARGE_INTESTINE	DUMP metabolic process →	+0.123	+1.483	.017	.001	3	6
BLOOD_Myeloma	Process utilizing autophagic mechanism →	-0.064	-0.695	.001	.016	3	5
BLOOD_Myeloma	Leading strand elongation →	+0.121	+0.712	.008	.014	3	5
BLOOD_Myeloma	Autophagy →	-0.064	-0.695	.001	.016	3	5
BLOOD_Myeloma	Negative regulation of protein deubiquitination →	-0.113	-1.202	.002	.006	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GW843682X response vs Pancreatic juice secretion — LARGE_INTESTINE

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